Protropin® (somatrem for injection) is a polypeptide hormone produced by recombinant DNA technology. Protropin has 192 amino acid residues and a molecular weight of about 22,000 daltons. The product contains the identical sequence of 191 amino acids constituting pituitary-derived human growth hormone plus an additional amino acid, methionine, on the N-terminus of the molecule. Protropin is synthesized in a special laboratory strain of E. coli bacteria which has been modified by the addition of the gene for human growth hormone production.
Unlike many brands of HGH therapy, Protropin is not biologically identical to natural human growth hormone, but it is functionally identical, meaning that it promotes the same physiological changes within the human body. In fact, somatropin (bio-identical HGH) and somatrem are nearly exactly the same, with only one molecular difference-an extra methionine molecule attached to the end of the compound.
Protropin is a highly purified preparation. Biological potency is determined by measuring the increase in body weight induced in hypophysectomized rats.
Protropin is a sterile, white, lyophilized powder intended for intramuscular or subcutaneous administration after reconstitution with Bacteriostatic Water for Injection, USP (benzyl alcohol preserved). Lyophilized simply means that medication is freeze-dried in order to extend its potency and storage longevity. Reconstitution is a simple process in which purified water is added to the freeze-dried Protropin, restoring it to an active state for injection. In the case of Protropin, the water is combined with preservatives in order to extend the life of the reconstituted treatment.
Each 5 mg Protropin vial contains 5 mg (approximately 15 IU) somatrem, lyophilized with 40 mg mannitol, and 1.7 mg sodium phosphates (0.1 mg sodium phosphate monobasic and 1.6 mg sodium phosphate dibasic).
Each 10 mg Protropin vial contains 10 mg (approximately 30 IU) somatrem, lyophilized with 80 mg mannitol, and 3.4 mg sodium phosphates (0.2 mg sodium phosphate monobasic and 3.2 mg sodium phosphate dibasic).
Phosphoric acid may be used for pH adjustment.
Bacteriostatic Water for Injection, USP is a sterile water containing 0.9 percent benzyl alcohol per mL as an antimicrobial preservative packaged in a multi-dose vial. The diluent pH is 4.5-7.0.
What is Protropin used for?
Protropin® (somatrem for injection) is indicated only for the long- term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion. Other etiologies of short stature should be excluded. Protropin was the first recombinant-DNA medication ever created.
How to get a prescription for Protropin
Protropin is no longer used in the United States, and is no longer available for use as an HGH deficiency treatment. Today, bio-identical HGH treatments are exclusively used for the FDA-approved treatment of human growth hormone deficiency, along with sermorelin acetate, which can be prescribed off-label, unlike HGH.
To get started with your own co-created HGH, Testosterone, Sermorelin or HCG therapy program, please fill out the contact form on the right hand side of our site and then give us a call at 1-800-648-9755. Although Protropin is no longer available in America, we can direct you toward a number of other medications that can treat HGH deficiency effectively.